Why enteric coated prednisolone

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search SpringerLink Search. Summary Prednisolone absorption and bioavailability of 10 mg enteric-coated EC and plain uncoated tablets were investigated after fasting and heavy meals EC only consumed to satiety in normal healthy volunteers.

References 1. Arthritis Rheum Google Scholar 3. J Pharm Sci — Google Scholar 5. Br Med J — Google Scholar 6. Therapie 5—7 Google Scholar 7. Br Med 1: — Google Scholar 8. Br Med J 1: — Google Scholar 9.

Postgrad Med J — Google Scholar J Pharmacokinet Biopharm 2: — Google Scholar J Clin Pharmacol — Google Scholar Gastroenterology — Google Scholar J Pharmacol Methods 6: — Google Scholar J Pharm Sci — Google Scholar Pharmacol Ther — Google Scholar Pharmacol Ther 53—72 Google Scholar The rise in prednisolone concentration was delayed between one and four hours when EC was used, and in some volunteers, was not absorbed at all.

Food had no effect on standard prednisolone absorption, but significantly delayed EC further. An example of the prednisolone profiles from one of the volunteers is shown. An early peak in prednisolone levels is required to mimic normal circadian physiology. Because the enteric coating delays this variably, we would recommend that EC prednisolone is avoided when prednisolone is used as a replacement for primary adrenal insufficiency.

A reliable and early peak is seen in patients and volunteers who take a single dose of standard prednisolone once daily, and we recommend that prednisolone replacement is taken first thing on waking. Harrogate, UK 06 Nov - 08 Nov Source Filter Source options. Filter by Date Filter results by date: From Enter date in the format yyyy-mm-dd.

To Enter date in the format yyyy-mm-dd. Accredited Accredited. Add this result to my export selection. Type: Evidence Summaries Add filter. Source: Specialist Pharmacy Service Add filter. Type: Prescribing and Technical Information Add filter. This is reflected in the BNF which states there is no conclusive evidence that the use of EC preparations of prednisolone reduces the risk of PU.

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